Acute Oral Toxicity Studies

Oral Exposure is the most significant route of exposure of free ranging birds to pesticides, xenobiotics and other active agents. Testing the effect of oral toxicity of prospective compounds on species for which a substantial toxicity database exists is a preferred means of determining mean lethal concentration ( LC50), lowest lethal dose (LLD)and no observable effect level (NOEL) concentrations. Springborn Smithers Laboratories has both the experience and the facilities to perform this type of study to fulfill the requirements of the EPA, EU Council and other regulatory agencies.

Our considerable experience using Northern Bobwhite Quail, a species representative of upland game birds, make us a laboratory of choice for performing this type of analysis. We have the capacity to both hatch and rear this species as well as several other species of game and domestic foul. Our specifically designed enclosures and animal rooms allow us to provide precise climatic control over such conditions as photoperiod, humidity and temperature. While facilities are important, so are skilled personnel and our staff has the ability to evaluate sub-lethal effects such as changes in behavior, function and performance important to the successful interpretation study data.

When required our newly updated analytical facilities can determine such parameters as active ingredient, physical properties, molecular weight, solubility, vapor pressure and molecular formula. Springborn Smithers' proven track record in acute toxicological studies means that your studies will not only come in on budget and on time but will be given the professional attention that you expect from a world class facility.